A voxel‐based morphometry comparison of the 3.0T ADNI‐1 and ADNI‐2 volumetric MRI protocols. (4th August 2014)

• Record Type: Journal Article
• Authors: Brunton, Simon; Gunasinghe, Cerisse; Jones, Nigel; Kempton, Matthew J; Westman, Eric; Simmons, Andrew
• Is Part Of: International journal of geriatric psychiatry. Volume 30:Number 5(2015:May)
• Page Start: 531
• Page End: 538
• Publication Date: 2014-08-04
• Subjects: ADNI‐1 -- ADNI‐2 -- MRI -- grey matter (GM) -- white matter (WM) -- cerebral spinal fluid (CSF); Geriatric psychiatry -- Periodicals; Geriatric Psychiatry -- Periodicals; 618.97689
• DOI: 10.1002/gps.4179
• Languages: English
• ISSNs: 0885-6230

Abstract

Abstract : Objectives: The Alzheimer's Disease Neuroimaging Initiative 3.0T MRI image acquisition scheme changed between the original ADNI‐1 grant and the two subsequent grants (ADNI‐GO and ADNI‐2). The aim of the current study was to investigate the compatibility of the 3.0T ADNI‐1 and ADNI‐2 T1‐weighted volumes using voxel‐based morphometry (VBM). Methods: T1‐weighted images of 30 subjects were acquired using a 3T GE Signa HDx using the ADNI‐1 and ADNI‐2 T1‐weighted volume sequences. Images were pre‐processed and analysed using SPM8. Global grey matter (GM), white matter (WM) and cerebrospinal fluid (CSF) volumes were compared, as well as voxel‐by‐voxel differences in GM and WM. Results: Correlation coefficients and percentage differences for each tissue type between ADNI‐1 and ADNI‐2 were as follows: ((GM: intraclass correlation coefficient (ICC) = 0.86, ADNI‐1 3.09% < ADNI‐2) (WM: ICC = 0.91, ADNI‐1 2.92% > ADNI‐2) (CSF: ICC = 0.90, ADNI‐1 1.94% > ADNI‐2)). For ADNI‐2, widespread increases in GM were found relative to ADNI‐1 (cerebellum and pre‐central gyrus), with localised decreases along the midline and temporal lobes. For ADNI‐1, widespread increases in WM were found relative to ADNI‐2 (cerebellum and pre‐central gyrus), together with localised decreases in the temporal gyrus. Conclusions: The widespread increase in GM and localised decrease in WM in ADNI‐2 compared to ADNI‐1 images suggests that the image acquisition protocols are not directly comparable using SPM‐8. Total volumes of GM, WM and CSF also differed between the protocols in the following order of magnitude: GM > WM > CSF. This has implications for studies aiming to analyse images acquired using the ADNI‐1 and ADNI‐2 protocols under VBM. © 2014 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd.