Dolutegravir-induced liver injury leading to sub-acute liver failure requiring transplantation: a case report and review of literature. (March 2018)

• Record Type: Journal Article
• Authors: Wang, Bo; Abbott, Laura; Childs, Kate; Taylor, Chris; Agarwal, Kosh; Cormack, Ian; Miquel, Rosa; Suddle, Abid
• Is Part Of: International journal of STD & AIDS. Volume 29:Number 4(2018)
• Page Start: 414
• Page End: 417
• Publication Date: 2018-03
• Subjects: Antiretroviral therapy -- human immunodeficiency virus -- toxicity -- dolutegravir -- liver; Sexually transmitted diseases -- Periodicals; AIDS (Disease) -- Periodicals; 616.951
• DOI: 10.1177/0956462417734099
• Languages: English
• ISSNs: 0956-4624

Abstract

A patient with human immunodeficiency virus-1 infection presented with sub-acute liver failure, temporally related to commencement of an antiretroviral therapy regimen containing dolutegravir (Triumeq). The patient was not a carrier of HLA-B5701, and abacavir hypersensitivity was unlikely. We believe this is the first report of severe dolutegravir-related hepatotoxicity resulting in sub-acute liver failure and transplantation and highlights a potential need for closer monitoring after drug initiation.