The first wave of B lymphopoiesis develops independently of stem cells in the murine embryo. Issue 1 (26th February 2015)

• Record Type: Journal Article
• Authors: Yoshimoto, Momoko
• Other Names: Rothstein Thomas L. guestEditor.; Herzenberg Leonore A. guestEditor.; Holodick Nichol E. guestEditor.; Ghosn Eliver guestEditor.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1362:Issue 1(2015)
• Page Start: 16
• Page End: 22
• Publication Date: 2015-02-26
• Subjects: B‐1 -- marginal zone B cells -- yolk sac -- para‐aortic splanchnopleura -- hematopoietic stem cells -- core‐binding factor β, hemogenic endothelial cells; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.12612
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract : In the developing mouse embryo, there are several waves of hematopoiesis. Primitive and definitive erythromyeloid lineages appear prior to hematopoietic stem cell (HSC) emergence, and these waves are considered to be transient and support embryonic homeostasis until HSC‐derived hematopoiesis is established. However, recent evidence strongly suggests that HSC‐independent immune cells, such as tissue macrophages and some innate lymphoid cells, develop in the mouse embryo and persist into postnatal life. Innate type B‐1 cells have also been reported to emerge from hemogenic endothelial cells in the extraembryonic yolk sac and para‐aortic splanchnopleura, and continue to develop in the fetal liver, even in HSC‐deficient mouse embryos. Here, this review discusses B‐1 cell development in the context of the layered immune system hypothesis of B lymphopoiesis and the emergence of B‐1 cells independent of HSCs.