Disseminated Lichtheimia ramosa Infection After Hematopoietic Stem Cell Transplantation in a Child With Chronic Granulomatous Disease. Issue 12 (December 2017)

• Record Type: Journal Article
• Authors: Winstead, Michael; Ozolek, John; Nowalk, Andrew; Williams, John; Vander Lugt, Mark; Lin, Philana
• Is Part Of: Pediatric infectious disease journal. Volume 36:Issue 12(2017)
• Publication Date: 2017-12
• Subjects: mucormycosis -- chronic granulomatous disease -- pediatric -- stem cell transplantation -- thrombosis; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000001589
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Mucormycosis is uncommon in patients with chronic granulomatous disease (CGD). We report a 7-year-old boy with X-linked CGD and absent oxidative burst who developed fatal Lichtheimia ramosa infection with fungal thrombosis of the kidneys, spleen and other organs after hematopoietic stem cell transplantation. Lichtheimia infection is rarely reported in patients with CGD and could be related to iatrogenic immunosuppression.