Comparison of 68Ga-PSMA PET/CT and multiparametric MRI for staging of high-risk prostate cancer68Ga-PSMA PET and MRI in prostate cancer. Issue 12 (December 2017)

• Record Type: Journal Article
• Authors: Tulsyan, Shruti; Das, Chandan J.; Tripathi, Madhavi; Seth, Amlesh; Kumar, Rajeev; Bal, Chandrasekhar
• Is Part Of: Nuclear medicine communications. Volume 38:Issue 12(2017:Dec.)
• Publication Date: 2017-12
• Subjects: gallium-68 prostate-specific membrane antigen -- high-risk prostate cancer -- multiparametric MRI -- PET/CT; Nuclear medicine -- Periodicals; 616.07575
• DOI: 10.1097/MNM.0000000000000749
• Languages: English
• ISSNs: 0143-3636

Abstract

Abstract : Introduction: We carried out this study to compare Glu-NH-CO-NH-Lys-(Ahx) [ 68 Ga(HBED-CC)] [ 68 Ga prostate-specific membrane antigen-11 (PSMA-11)] PET with multiparametric MRI (mpMRI) for the staging of high-risk prostate cancer. Patients and methods: This was a prospective study in which 36 patients with high-risk prostate cancer were included. The criteria for inclusion were biopsy-proven prostate cancer with a serum prostate specific antigen of at least 20 and/or Gleason's score of at least 8. Each patient then underwent both gallium-68 ( 68 Ga)-PSMA PET/computed tomography (CT) and mpMRI including diffusion-weighted whole-body imaging with background body signal suppression within an interval of 1 week and both modalities were compared for staging of primary disease, lymph node, and distant metastasis. Results: The median age of the 36 patients included was 65 years (range: 44–80 years) and the median prostate specific antigen was 94.3 ng/ml (range: 20–19005 ng/ml). Concordance for localization of primary on 68 Ga-PSMA PET/CT and MRI was observed in 19/36 (52.7%) patients. Concurrence for T staging on 68 Ga-PSMA and MRI was observed in 58.3% of patients. 68 Ga-PSMA PET/CT detected higher numbers of patients with regional (29) and nonregional (15) lymph nodes in comparison with MRI (20 and 5, respectively). Concurrence for regional and nonregional lymph node staging was observed in 72.2% of patients. Additional sites of metastatic disease reported on 68 Ga-PSMA PET/CT were to the skeleton in one patient, the lung in two patients, and the liver in one patient. Conclusion: This study suggests that 68 Ga-PSMA PET/CT is useful for lymph node and metastases staging in high-risk prostate cancers, whereas its utility for staging of disease in the prostate is limited.