Antialbuminuric effect of eplerenone in comparison to thiazide diuretics in patients with hypertension. Issue 10 (28th August 2017)

• Record Type: Journal Article
• Authors: Sawai, Toshiki; Dohi, Kaoru; Fujimoto, Naoki; Okubo, Setsuya; Isaka, Naoki; Ichikawa, Takehiko; Makino, Katsutoshi; Okamoto, Shinya; Koyabu, Sukenari; Kitamura, Tetsuya; Ogura, Toru; Yamada, Tomomi; Tamaru, Satoshi; Nishikawa, Masakatsu; Nakamura, Mashio; Ito, Masaaki
• Other Names: Ito Masaaki investigator.; Nishimura Yuki investigator.; Fujii Eitaro investigator.; Omura Takashi investigator.; Mori Takuya investigator.; Takeuchi Tetsushiro investigator.; Okamoto Ryuji investigator.; Murata Tomohiro investigator.; Senga Michiharu investigator.; Ishikawa Eiji investigator.; Osugi Kazuki investigator.; Tanimura Muneyoshi investigator.; Ito Hiroo investigator.; Fujita Satoshi investigator.; Nakajima Hiroshi investigator.; Uraki Satoko investigator.; Nojiri Keiichiro investigator.; Mizutani Hideo investigator.; Yamada Norikazu investigator.; Konishi Katsuhisa investigator.; Matsuyama Sonoko investigator.; Iwasaki Hitoshi investigator.; Tanigawa Takashi investigator.; Taniguchi Masaya investigator.; Watanabe Kiyotaka investigator.; Ota Satoshi investigator.; Shiraki Katsuya investigator.; Hotta Yasuhiro investigator.; Izumi Daisuke investigator.; Tsuji Akihiro investigator.; Kakuta Kentaro investigator.; Sugiura Emiyo investigator.; Matsuda Akimasa investigator.; Sugimoto Tadafumi investigator.; Seko Tetsuya investigator.; Hamanaka Yoshimi investigator.; Tsujimoto Yukako investigator.; Kotera Mayumi investigator.; Minamide Chisato investigator.; Kurimoto Rie investigator.; Muramatsu Sanae investigator.;
• Is Part Of: Journal of clinical hypertension. Volume 19:Issue 10(2017)
• Page Start: 990
• Page End: 998
• Publication Date: 2017-08-28
• Subjects: antihypertensive therapy -- clinical trials -- combination therapy -- proteinuria -- renal disease; Hypertension -- Periodicals; 616.132
• DOI: 10.1111/jch.13054
• Languages: English
• ISSNs: 1524-6175

Abstract

Abstract : This study investigated the effects and safety of eplerenone or thiazide diuretics in patients with hypertension and albuminuria (pretreatment urinary albumin/creatinine ratio ≥10 mg/gCr) treated with an angiotensin II receptor blocker. The primary end point was the mean percent change in the urinary albumin/creatinine ratio from baseline to 48 weeks. An efficacy analysis was performed in 195 patients (98 in the eplerenone group and 97 in the thiazide group). Systolic and diastolic blood pressures at 48 weeks were similar in the two groups. The mean percent change in the urinary albumin/creatinine ratio from baseline to 48 weeks was similar in the two groups ( P =.804). In the safety analysis, the withdrawal rates for adverse events were similar in both groups. The antialbuminuric effects and safety of eplerenone therapy were similar to those of thiazide diuretics when combined with an angiotensin II receptor blocker in patients with hypertension and albuminuria.