The concept of fraction of drug transported (ft) with special emphasis on BBB efflux of CNS and antiretroviral drugs. Issue 4 (13th February 2015)

• Record Type: Journal Article
• Authors: Prasad, B; Unadkat, JD
• Is Part Of: Clinical pharmacology & therapeutics. Volume 97:Issue 4(2015:Apr.)
• Page Start: 320
• Page End: 323
• Publication Date: 2015-02-13
• Subjects: Pharmacology -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1002/cpt.72
• Languages: English
• ISSNs: 0009-9236

Abstract

Abstract : The fraction of drug transported (ft ) into or out of a tissue is a concept useful to understand the impact of transporters on absorption, distribution, metabolism, and excretion (ADME) and tissue distribution of a drug. Here, ft is utilized to explain the impact of transporters on central nervous system (CNS) distribution of drugs, drug interactions (DDI), and to predict the unbound brain concentration (Cu, b ) of the drug. The latter is important to ascertain if Cu, b is sufficient for efficacy.