Rational Design and Synthesis of Efficient Sunscreens To Boost the Solar Protection Factor. Issue 10 (27th January 2017)

• Record Type: Journal Article
• Authors: Losantos, Raúl; Funes‐Ardoiz, Ignacio; Aguilera, José; Herrera‐Ceballos, Enrique; García‐Iriepa, Cristina; Campos, Pedro J.; Sampedro, Diego
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 10(2017)
• Page Start: 2632
• Page End: 2635
• Publication Date: 2017-01-27
• Subjects: ab initio calculations -- chromophores -- photoprotection -- sunscreens; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201611627
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Skin cancer incidence has been increasing in the last decades, but most of the commercial formulations used as sunscreens are designed to protect only against solar erythema. Many of the active components present in sunscreens show critical weaknesses, such as low stability and toxicity. Thus, the development of more efficient components is an urgent health necessity and an attractive industrial target. We have rationally designed core moieties with increased photoprotective capacities and a new energy dissipation mechanism. Using these scaffolds, we have synthesized a series of compounds with tunable properties suitable for their use in sunscreens, and enhanced properties in terms of stability, light energy dissipation, and toxicity. Moreover, some representative compounds were included in final sunscreen formulations and a relevant solar protection factor boost was measured. Abstract : Soak up some rays : Inspired by naturally occurring compounds, a new family of efficient sunscreens was rationally designed and synthesized. Their properties as sunscreens were tested and found to boost the solar protection factor in real samples.