Immunopathology alters Th17 cell glucocorticoid sensitivity. Issue 3 (13th October 2016)

• Record Type: Journal Article
• Authors: Banuelos, J.; Cao, Y.; Shin, S. C.; Lu, N. Z.
• Is Part Of: Allergy. Volume 72:Issue 3(2017:Mar.)
• Page Start: 331
• Page End: 341
• Publication Date: 2016-10-13
• Subjects: asthma -- autoimmunity -- glucocorticoid resistance -- glucocorticoids -- Th17 cells; Allergy -- Periodicals; 616.97
• DOI: 10.1111/all.13051
• Languages: English
• ISSNs: 0105-4538

Abstract

Abstract: Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects in Th17‐related diseases alter glucocorticoid sensitivity of Th17 cells. We identify molecular pathways that are implicated in glucocorticoid sensitivity of Th17 cells in the literature, as this information is useful for developing approaches to overcome glucocorticoid‐resistant immunopathology.