An Eco‐friendly Synthesis of Some Novel 4‐methyl‐4‐hetaryl Chromene and Pyrano[2, 3‐c]pyrazole Derivatives. (7th March 2017)

• Record Type: Journal Article
• Authors: Abdelrazek, Fathy M.; Metz, Peter; Jäger, Anne; Metwally, Nadia H.
• Is Part Of: Journal of heterocyclic chemistry. Volume 54:Number 4(2017:Jul.)
• Page Start: 2313
• Page End: 2318
• Publication Date: 2017-03-07
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2819
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : Some novel chromene and pyrano[2, 3‐ c ]pyrazole derivatives could be achieved successfully by reacting cyclic β‐diketones with 2‐acetylfuran/2‐acetylthiophene and malononitrile in a one‐pot synthesis. Active methylene pyrazolones reacted with 2‐(1‐furan‐2‐yl‐ethylidene)‐malononitrile and 2‐(1‐thiophen‐2‐yl‐ethylidene)‐malononitrile derivatives to afford the desired pyrano[2, 3‐ c ]pyrazole derivatives. Structures of all new compounds were established based on analytical and spectral data as well as X‐ray crystallography. A plausible mechanism for the reaction is suggested. The solvents and catalyst used are environmentally benign, and no hazardous solvents or heavy metals were involved. Abstract :