New Synthesis of 7‐(3‐chloropropoxy)‐4‐hydroxy‐6‐methoxyquinoline‐3‐carbonitrile, a Key Intermediate to Bosutinib. (5th March 2017)
- Record Type:
- Journal Article
- Title:
- New Synthesis of 7‐(3‐chloropropoxy)‐4‐hydroxy‐6‐methoxyquinoline‐3‐carbonitrile, a Key Intermediate to Bosutinib. (5th March 2017)
- Main Title:
- New Synthesis of 7‐(3‐chloropropoxy)‐4‐hydroxy‐6‐methoxyquinoline‐3‐carbonitrile, a Key Intermediate to Bosutinib
- Authors:
- Zhu, Guoqing
Sun, Mingchen
Zhu, Chunping
Wang, Han
Xu, Jingli - Abstract:
- Abstract : A new and convenient synthesis of 7‐(3‐chloropropoxy)‐4‐hydroxy‐6‐methoxyquinoline‐3‐carbonitrile, the key intermediate to bosutinib, is described on a hectogram scale. 5‐Bromo‐2‐methoxyphenol is adopted as the starting material via the simple chemical process including Friedel‐Crafts reaction, alkylation, bromination, cyano substitution, and so on to give the 3‐amino‐2‐(2‐bromobenzoyl)acrylonitrile compound25, which underwent key intramolecular cyclization at K2 CO3 /DMF condition; the title product was obtained in 36.9% yield over 7 steps and 98.71% purity (HPLC). Abstract :
- Is Part Of:
- Journal of heterocyclic chemistry. Volume 54:Number 4(2017:Jul.)
- Journal:
- Journal of heterocyclic chemistry
- Issue:
- Volume 54:Number 4(2017:Jul.)
- Issue Display:
- Volume 54, Issue 4 (2017)
- Year:
- 2017
- Volume:
- 54
- Issue:
- 4
- Issue Sort Value:
- 2017-0054-0004-0000
- Page Start:
- 2237
- Page End:
- 2241
- Publication Date:
- 2017-03-05
- Subjects:
- Heterocyclic compounds -- Periodicals
547.59 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/jhet.2811 ↗
- Languages:
- English
- ISSNs:
- 0022-152X
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4998.200000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 8620.xml