Pyrimidine and Pyrazole Linked Azetidin‐2‐ones: Entry to Novel Class of β‐Lactam Heterocycles. (7th March 2017)

• Record Type: Journal Article
• Authors: Bhalla, Jitender; Bari, Shamsher S.; Rathee, Aditi; Kumar, Ashok; Bhalla, Aman
• Is Part Of: Journal of heterocyclic chemistry. Volume 54:Number 4(2017:Jul.)
• Page Start: 2297
• Page End: 2306
• Publication Date: 2017-03-07
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2817
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : A novel series of pyrimidine/pyrazole linked β‐lactams have been synthesized in excellent yields using a simple and efficient methodology involving conjunction of different heterocyclic substrates. All the new products were characterized on the basis of various spectroscopic techniques viz. FT‐IR, 1 H NMR, 13 C NMR, elemental analysis (CHN), 1 H‐ 1 H correlation spectroscopy ( 1 H‐ 1 H COSY) and mass spectrometry (EIMS) in representative cases. Furthermore, theoretical calculations have also been performed on representative compounds and the results were compared with C efuroxime axetil (a broad spectrum antibacterial agent). The phenomenon of tautomerism was also observed which was confirmed by different NMR experiments (D2 O exchange study and 1 H‐ 1 H correlation spectroscopy). Abstract :