Dissolvable Base Scaffolds Allow Tissue Penetration of High‐Aspect‐Ratio Flexible Microneedles. Issue 13 (2nd August 2015)

• Record Type: Journal Article
• Authors: Yagi, Satoshi; Yamagiwa, Shota; Kubota, Yoshihiro; Sawahata, Hirohito; Numano, Rika; Imashioya, Tatsuya; Oi, Hideo; Ishida, Makoto; Kawano, Takeshi
• Is Part Of: Advanced healthcare materials. Volume 4:Issue 13(2015)
• Page Start: 1949
• Page End: 1955
• Publication Date: 2015-08-02
• Subjects: brain -- microneedles -- penetration -- silicon -- silk; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201500305
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Microscale needle technology is important in electrophysiological studies, drug/chemical delivery systems, optogenetic applications, and so on. In this study, dissolvable needle‐base scaffold realizes penetration of high‐aspect‐ratio flexible microneedles (e.g., <5 μm diameter and >500 μm length) into biological tissues. This methodology, which is applicable to numerous high‐aspect‐ratio flexible microneedles, should reduce the invasiveness and provide safer tissue penetrations than conventional approaches.