Synthesis, Antimicrobial Activity and Molecular Docking Study of Thiazole Derivatives. (13th March 2017)

• Record Type: Journal Article
• Authors: Farghaly, Thoraya A.; Abdallah, Magda A.; Khedr, Mohammed A.; Mahmoud, Huda K.
• Is Part Of: Journal of heterocyclic chemistry. Volume 54:Number 4(2017:Jul.)
• Page Start: 2417
• Page End: 2425
• Publication Date: 2017-03-13
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2838
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : The reaction of 4‐thiochromane thiocarbohydrazone with a series of hydrazonoyl halides in dioxane in the presence of triethylamine afforded novel thiochromane derivatives incorporating 1, 3‐thiazole moiety. The structure of the latter compounds was established by elemental analysis and spectral technique and by their chemical transformation. Moreover, the antimicrobial activity of the newly synthesized compounds was screened and the results showed that some compounds have higher activity than the applied fungicide and bactericide. The antimicrobial activity of the most active compounds was interpreted by molecular docking study. Abstract :