Fraxitoxin, a New Isochromanone Isolated from Diplodia fraxini. Issue 11 (21st November 2017)

• Record Type: Journal Article
• Authors: Cimmino, Alessio; Maddau, Lucia; Masi, Marco; Linaldeddu, Benedetto T.; Pescitelli, Gennaro; Evidente, Antonio
• Is Part Of: Chemistry & biodiversity. Volume 14:Issue 11(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-11-21
• Subjects: Ash dieback -- Diplodia fraxini -- Phytotoxicity -- Isochromanones -- Fraxitoxin; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201700325
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract : A new isochromanone, named fraxitoxin, was isolated together with (–)‐mellein and tyrosol from liquid cultures of Diplodia fraxini, a pathogen involved in the etiology of canker and dieback disease of Fraxinus spp. in Europe. It was characterized as 5‐methoxy‐3‐methylisochroman‐1‐one using spectroscopic methods (essentially NMR and HR‐EI‐MS). Its absolute configuration ( R ) at C(3) was assigned by electronic circular dichroism (ECD) measurements and calculations. Phytotoxic activity of the compound was evaluated on ash, cork and holm oak leaves at concentration of 1 mg/ml by the leaf‐puncture assay. Interestingly, fraxitoxin caused necrotic lesions only on ash leaves. Abstract :