Structural Modification of Stilbenoids from Acanthopanax leucorrhizus and Their Cytotoxic Activity. Issue 11 (24th November 2017)

• Record Type: Journal Article
• Authors: Hu, Hao‐Bin; Liang, Hai‐Peng; Li, Hai‐Ming; Yuan, Ru‐Nan; Sun, Jiao; Wu, Yun; Zhang, La‐La; Han, Ming‐Hu
• Is Part Of: Chemistry & biodiversity. Volume 14:Issue 11(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-11-24
• Subjects: Acanthopanax leucorrhizus -- Stilbenoids -- Isolation -- Structural modification -- Cytotoxic activity; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201700244
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract : A new cis ‐stilbenoid, 1, 9‐dihydroxy‐10‐methoxy‐6 H ‐dibenzo[ b, f ]oxocin‐6‐one (2 ) was isolated from the AcOEt extract of the stem barks of Acanthopanax leucorrhizus, along with three known stilbenoids, 9‐hydroxy‐10‐methoxy‐6 H ‐dibenzo[ b, f ]oxocin‐6‐one (1 ), 5‐ O ‐methyl‐( E )‐resveratrol 3‐ O ‐ β ‐d ‐glucopyranoside (3 ), and ( E )‐resveratrol 3‐ O ‐ β ‐d ‐xylopyranoside (4 ). Two derivatives (2a and2b ) were synthesized by the structural modification of compound2, which exhibited certain cytotoxic activities against HT‐29 and HeLa cell lines in vitro . All compounds were structurally characterized by comprehensive analysis of their spectroscopic data and comparison with literature information, and evaluated for their cytotoxic activities against three human tumor cell lines (HL‐60, HT‐29, and HeLa) by the standard MTT assay in vitro . The results showed that derivatives2a and2b exhibited strong activities than compounds2 against HT‐29 and HeLa cell lines. Abstract :