Bronchiectasis following treatment for high‐risk neuroblastoma: A case series. Issue 10 (10th March 2017)

• Record Type: Journal Article
• Authors: Adams, Madeleine; Traunecker, Heidi; Doull, Iolo; Cox, Rachel
• Is Part Of: Pediatric blood & cancer. Volume 64:Issue 10(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-03-10
• Subjects: bronchiectasis -- hypogammaglobulinaemia -- neuroblastoma; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26509
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: High‐risk (HR) neuroblastoma remains a very challenging disease to treat and long‐term cure is only possible with intensive, multimodal treatment including chemotherapy, high‐dose therapy, radiotherapy, surgery, and immunotherapy. As a result, treatment‐related morbidity and late effects are common in survivors. This report outlines a case series of six patients who developed a chronic productive cough following treatment for HR neuroblastoma. High‐resolution computed tomography scanning confirmed the diagnosis of bronchiectasis. Two of the patients who have undergone immunological testing demonstrate hypogammaglobulinaemia and impaired vaccine response. Persistent cough in patients treated for neuroblastoma warrants investigation and consideration of immunological referral.