The Impact of Mathematical Modeling in Understanding the Mechanisms Underlying Neurodegeneration: Evolving Dimensions and Future Directions. (7th January 2017)

• Record Type: Journal Article
• Authors: Lloret‐Villas, A; Varusai, TM; Juty, N; Laibe, C; Le NovÈre, N; Hermjakob, H; Chelliah, V
• Is Part Of: CPT: pharmacometrics & systems pharmacology. Volume 6:Number 2(2017)
• Page Start: 73
• Page End: 86
• Publication Date: 2017-01-07
• Subjects: Pharmacokinetics -- Periodicals; Pharmacology -- Periodicals; Pharmacokinetics; Periodicals; 615.05
• DOI: 10.1002/psp4.12155
• Languages: English
• ISSNs: 2163-8306

Abstract

Abstract : Neurodegenerative diseases are a heterogeneous group of disorders that are characterized by the progressive dysfunction and loss of neurons. Here, we distil and discuss the current state of modeling in the area of neurodegeneration, and objectively compare the gaps between existing clinical knowledge and the mechanistic understanding of the major pathological processes implicated in neurodegenerative disorders. We also discuss new directions in the field of neurodegeneration that hold potential for furthering therapeutic interventions and strategies.