Tunable Delivery of siRNA from a Biodegradable Scaffold to Promote Angiogenesis In Vivo. (16th December 2013)

• Record Type: Journal Article
• Authors: Nelson, Christopher E.; Kim, Arnold J.; Adolph, Elizabeth J.; Gupta, Mukesh K.; Yu, Fang; Hocking, Kyle M.; Davidson, Jeffrey M.; Guelcher, Scott A.; Duvall, Craig L.
• Is Part Of: Advanced materials. Volume 26:Number 4(2014)
• Page Start: 607
• Page End: 614
• Publication Date: 2013-12-16
• Subjects: gene knockdown -- controlled release -- reversible addition‐fragmentation chain transfer (RAFT) polymerization, endosomolytic nanoparticles, injectable scaffolds; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201303520
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : A system is engineered for temporally controlled delivery of siRNA from biodegradable tissue regenerative scaffolds. Therapeutic application of this approach to silence PHD2 promotes expression of pro‐angiogenic genes controlled by HIF1α and enhanced scaffold vascularization in vivo. This technology provides a new standard for efficient and controllable gene silencing to modulate host response within regenerative biomaterials.