Boosting the Catalytic Performance of Metal–Organic Frameworks for Steroid Transformations by Confinement within a Mesoporous Scaffold. Issue 43 (25th September 2017)

• Record Type: Journal Article
• Authors: Cirujano, Francisco G.; Luz, Ignacio; Soukri, Mustapha; Van Goethem, Cedric; Vankelecom, Ivo F. J.; Lail, Marty; De Vos, Dirk E.
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 43(2017)
• Page Start: 13302
• Page End: 13306
• Publication Date: 2017-09-25
• Subjects: active-site confinement -- mesoporous silica -- MOF composites -- nanoMOFs -- steroid chemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201706721
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Solid‐state crystallization achieves selective confinement of metal–organic framework (MOF) nanocrystals within mesoporous materials, thereby rendering active sites more accessible compared to the bulk‐MOF and enhancing the chemical and mechanical stability of MOF nanocrystals. (Zr)UiO‐66(NH2 )/SiO2 hybrid materials were tested as efficient and reusable heterogeneous catalysts for the synthesis of steroid derivatives, outperforming the bulk (Zr)UiO‐66(NH2 ) MOF. A clear correlation between the catalytic activity of the dispersed Zr sites present in the confined MOF, and the loading of the mesoporous SiO2, is demonstrated for steroid transformations. Abstract : Sentenced to solitary : Confinement of UiO‐66 metal–organic framework (MOF) nanocrystals inside the pores of SBA‐15 mesoporous silica promotes MOF‐catalyzed transformations of bulky steroids, while simultaneously enhancing the chemical and mechanical stability of the MOF.