Biodegradable polyanhydride‐based nanomedicines for blood to brain drug delivery. Issue 11 (26th October 2018)

• Record Type: Journal Article
• Authors: Brenza, Timothy M.; Schlichtmann, Benjamin W.; Bhargavan, Biju; Vela Ramirez, Julia E.; Nelson, Rainie D.; Panthani, Matthew G.; McMillan, JoEllyn M.; Kalyanaraman, Balaraman; Gendelman, Howard E.; Anantharam, Vellareddy; Kanthasamy, Anumantha G.; Mallapragada, Surya K.; Narasimhan, Balaji; Kanmogne, Georgette D.
• Is Part Of: Journal of biomedical materials research. Volume 106:Issue 11(2018)
• Page Start: 2881
• Page End: 2890
• Publication Date: 2018-10-26
• Subjects: nanoparticles -- blood–brain barrier -- cell‐mediated transcytosis -- polyanhydrides -- mito‐apocynin; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.36477
• Languages: English
• ISSNs: 1549-3296

Abstract

Abstract: An urgent need to deliver therapeutics across the blood–brain barrier (BBB) underlies a paucity of effective therapies currently available for treatment of degenerative, infectious, traumatic, chemical, and metabolic disorders of the nervous system. With an eye toward achieving this goal, an in vitro BBB model was employed to simulate biodegradable polyanhydride nanoparticle‐based drug delivery to the brain. Using a combination of confocal microscopy, flow cytometry, and high performance liquid chromatography, we examined the potential of polyanhydride nanoparticles containing the anti‐oxidant, mito‐apocynin, to be internalized and then transferred from monocytes to human brain microvascular endothelial cells. The efficacy of this nanoparticle‐based delivery platform was demonstrated by neuronal protection against oxidative stress. Taken together, this polyanhydride nanoparticle‐based delivery system holds promise for enhancing neuroprotection by facilitating drug transport across the BBB. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2881–2890, 2018.