Synthesis and in vitro anticancer properties of a novel neodymium(III) complex containing tungstogermanate and 5-fluorouracil. Issue 14 (18th July 2018)

• Record Type: Journal Article
• Authors: Liu, Haibin; Zhou, Baoyang; Zhao, Ce; Zhang, Danfeng; Wu, Qingyin; Li, Zengqiang
• Is Part Of: Journal of coordination chemistry. Volume 71:Issue 14(2018)
• Page Start: 2102
• Page End: 2108
• Publication Date: 2018-07-18
• Subjects: Polyoxometalate -- 5-Fluorouracil -- rare earth -- anticancer; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2018.1472771
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: A novel neodymium(III) complex containing tungstogermanate and 5-fluorouracil, K11 (C4 H4 FN2 O2 )2 Nd(GeW11 O39 )2 ·15H2 O (FNdGeW), was synthesized and its structure was characterized by 1 H NMR, IR, XRD, and TG-DSC. The results indicated that FNdGeW had Keggin structure of hetereopolyanion and structure of 5-fluorouracil. The thermal analysis showed that FNdGeW decomposed at 255.3 °C. MTT tests were performed to study the anticancer activities against SGC-7901 and HepG2 cells. The results showed that FNdGeW and FGeW possessed higher anticancer activities than 5-fluorouracil. FNdGeW exhibited the highest anticancer activities against SGC-7901 cells (IC50 = 0.79 μmolL -1 ) and HepG2 cells (IC50 = 0.37 μmolL -1 ). Abstract :