DNA Binding, amelioration of oxidative stress, and molecular docking study of Zn(II) metal complex of a new Schiff base ligand. Issue 14 (18th July 2018)

• Record Type: Journal Article
• Authors: Mishra, Dipu Kumar; Singha, Uttam Kumar; Das, Ananya; Dutta, Somit; Kar, Pallab; Chakraborty, Arnab; Sen, Arnab; Sinha, Biswajit
• Is Part Of: Journal of coordination chemistry. Volume 71:Issue 14(2018)
• Page Start: 2165
• Page End: 2182
• Publication Date: 2018-07-18
• Subjects: 3, 3′-Methylenedianiline -- 2-Hydroxy-5-nitro-benzaldehyde -- Zn(II) Complex -- DNA Cleavage -- molecular docking; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2018.1476687
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: A new Schiff base ligand, H2 L, and its Zn(II) complex were prepared and characterized by different analytical and spectroscopic techniques. The elemental analysis results suggest the stoichiometry of the complex to be 1:1. The molar conductance study shows the non-electrolytic nature of the complex. Infrared spectra reveal that the metal ion is coordinated in tetradentate fashion which was further confirmed by NMR study. The synthesized complex was found to interact with CT-DNA quite efficiently. The DNA binding study of the complex was explored by UV–vis and viscosity measurement. Fluorescence titration studies and the experimental results suggest that the complex might bind to DNA via an intercalative mode. The in silico target prediction and molecular docking experiments confirm that, apart from high interaction potentiality with nucleotides, the complex has possible implications in carcinogenesis, too. Abstract :