A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance. Issue 4 (4th July 2018)

• Record Type: Journal Article
• Authors: Ambrogio, Chiara; Darbo, Elodie; Lee, Sam W.; Santamaría, David
• Is Part Of: Cell adhesion & migration. Volume 12:Issue 4(2018)
• Page Start: 394
• Page End: 397
• Publication Date: 2018-07-04
• Subjects: cancer -- chemoresistance -- Discoidin Domain Receptor 1 -- RTK signalling -- receptor crosstalk; Cell adhesion -- Periodicals; Cell migration -- Periodicals; Cell interaction -- Periodicals; 574.876
• DOI: 10.1080/19336918.2018.1445954
• Languages: English
• ISSNs: 1933-6918

Abstract

ABSTRACT: The Discoidin Domain Receptor 1 (DDR1) receptor tyrosine kinase performs pleiotropic functions in the control of cell adhesion, proliferation, survival, migration, and invasion. Aberrant DDR1 function as a consequence of either mutations or increased expression has been associated with various human diseases including cancer. Pharmacological inhibition of DDR1 results in significant therapeutic benefit in several pre-clinical cancer models. Here, we discuss the potential implication of DDR1-dependent pro-survival functions in the development of cancer resistance to chemotherapeutic regimens and speculate on the molecular mechanisms that might mediate such important feature.