Geroneuroprotectors: Effective Geroprotectors for the Brain. (December 2018)

• Record Type: Journal Article
• Authors: Schubert, David; Currais, Antonio; Goldberg, Joshua; Finley, Kim; Petrascheck, Michael; Maher, Pamela
• Is Part Of: Trends in pharmacological sciences. Volume 39:Number 12(2018)
• Page Start: 1004
• Page End: 1007
• Publication Date: 2018-12
• Subjects: aging -- multimorbidity -- geroscience -- neuroprotection -- Alzheimer's disease -- drug discovery; Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2018.09.008
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : Geroprotectors are compounds that slow the rate of biological aging and therefore may reduce the incidence of age-associated diseases such as Alzheimer's disease (AD). However, few have therapeutic efficacy in mammalian AD models. Here we describe the identification of geroneuroprotectors (GNPs), novel AD drug candidates that meet the criteria for geroprotectors.