Patterns of care and outcomes of postoperative radiation for low-grade gliomas in United States hospitals. (December 2018)

• Record Type: Journal Article
• Authors: Youssef, Irini; Lee, Anna; Garay, Elizabeth L.; Becker, Daniel J.; Schreiber, David
• Is Part Of: Journal of clinical neuroscience. Volume 58(2018)
• Page Start: 124
• Page End: 129
• Publication Date: 2018-12
• Subjects: Postoperative radiation -- Low-grade gliomas -- NCDB -- High-risk; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2018.09.010
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: The National Cancer Database (NCDB) was analyzed for patterns of care in patients with low-grade gliomas. 26.5% of patients received postoperative radiation. Those with astrocytoma and high-risk factors were more likely to receive postoperative radiation. Patients who received radiation did not do better than those who did not receive radiation. Abstract: It is unclear whether there is a survival benefit with postoperative radiation for low-grade gliomas deemed to be high-risk. We sought to analyze patterns of care and outcomes of radiation use. We accessed the National Cancer Database to identify patients with WHO grade II oligodendroglioma or astrocytoma between 2010 and 2012. Multivariable logistic regression was used to identify predictors of radiation use and multivariable Cox regression was used to identify covariables associated with differences in survival. There were 1952 patients included in this study, of which 518 (26.5%) received postoperative radiation. The majority had oligodendroglioma histology (n = 1121, 57.4%) compared to astrocytoma (n = 831, 42.6%). There were 1626 patients who were either ≥40 years old or underwent a subtotal resection ("high-risk"), and from these 495 (30.4%) received postoperative radiation. On multivariable logistic regression treatment at an academic facility (OR 0.72) was associated with a lower likelihood of receiving postoperative radiation. Astrocytoma histology (OR 2.08), age ≥40 years (OR 2.23), tumor size ≥6 cm (OR 1.64), subtotal resection (OR 1.55), and chemotherapy use (OR 3.93) were associated with an increased likelihood of postoperative radiation. On multivariable analysis, astrocytoma histology (HR 3.49, p < 0.001) and receipt of radiation (HR 2.06, p < 0.001) were associated with worse overall survival. GTR (HR 0.51, p = 0.001) was associated with improved overall survival. Patients treated in United States hospitals are not routinely referred for postoperative radiation for high-risk, low-grade gliomas. Patients who received radiation did not do better than those who did not receive radiation.