THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. (21st October 2017)

• Record Type: Journal Article
• Authors: Alexander, Stephen PH; Kelly, Eamonn; Marrion, Neil V; Peters, John A; Faccenda, Elena; Harding, Simon D; Pawson, Adam J; Sharman, Joanna L; Southan, Christopher; Buneman, O Peter; Cidlowski, John A; Christopoulos, Arthur; Davenport, Anthony P; Fabbro, Doriano; Spedding, Michael; Striessnig, Jörg; Davies, Jamie A
• Other Names: Abbracchio M‐P investigator.; Aldrich R investigator.; Al‐Hosaini K investigator.; Arumugam TV investigator.; Attali B investigator.; Bäck M investigator.; Barnes NM investigator.; Bathgate R investigator.; Beart PM investigator.; Becirovic E investigator.; Bettler B investigator.; Biel M investigator.; Birdsall NJ investigator.; Blaho V investigator.; Boison D investigator.; Bräuner‐osborne H investigator.; Bröer S investigator.; Bryant C investigator.; Burnstock G investigator.; Calo G investigator.; Catterall WA investigator.; Ceruti S investigator.; Chan SL investigator.; Chandy KG investigator.; Chazot P investigator.; Chiang N investigator.; Chun JJ investigator.; Chung J‐J investigator.; Clapham DE investigator.; Clapp L investigator.; Connor MA investigator.; Cox HM investigator.; Davies P investigator.; Dawson PA investigator.; Decaen P investigator.; Dent G investigator.; Doherty P investigator.; Douglas SD investigator.; Dubocovich ML investigator.; Fong TM investigator.; Fowler CJ investigator.; Frantz A investigator.; Fuller P investigator.; Fumagalli M investigator.; Futerman AH investigator.; Gainetdinov RR investigator.; Gershengorn MA investigator.; Goldin A investigator.; Goldstein SAN investigator.; Goudet C investigator.; Gregory K investigator.; Grissmer S investigator.; Gundlach AL investigator.; Hagenbuch B investigator.; Hamann J investigator.; Hammond JR investigator.; Hancox JC investigator.; Hanson J investigator.; Hanukoglu I investigator.; Hay DL investigator.; Hobbs AJ investigator.; Hollenberg AN investigator.; Holliday ND investigator.; Hoyer D investigator.; Ijzerman AP investigator.; Inui KI investigator.; Irving AJ investigator.; Ishii S investigator.; Jacobson KA investigator.; Jan LY investigator.; Jarvis MF investigator.; Jensen R investigator.; Jockers R investigator.; Kaczmarek LK investigator.; Kanai Y investigator.; Karnik S investigator.; Kellenberger S investigator.; Kemp S investigator.; Kennedy C investigator.; Kerr ID investigator.; Kihara Y investigator.; Kukkonen J investigator.; Larhammar D investigator.; Leach K investigator.; Lecca D investigator.; Leeman S investigator.; Leprince J investigator.; Lolait SJ investigator.; Macewan D investigator.; Maguire JJ investigator.; Marshall F investigator.; Mazella J investigator.; Mcardle CA investigator.; Michel MC investigator.; Miller LJ investigator.; Mitolo V investigator.; Mizuno H investigator.; Monk PN investigator.; Mouillac B investigator.; Murphy PM investigator.; Nahon J‐L investigator.; Nerbonne J investigator.; Nichols CG investigator.; Norel X investigator.; Offermanns S investigator.; Palmer LG investigator.; Panaro MA investigator.; Papapetropoulos A investigator.; Perez‐reyes E investigator.; Pertwee RG investigator.; Pintor S investigator.; Pisegna JR investigator.; Plant LD investigator.; Poyner DR investigator.; Prossnitz ER investigator.; Pyne S investigator.; Ramachandran R investigator.; Ren D investigator.; Rondard P investigator.; Ruzza C investigator.; Sackin H investigator.; Sanger G investigator.; Sanguinetti MC investigator.; Schild L investigator.; Schiöth H investigator.; Schulte G investigator.; Schulz S investigator.; Segaloff DL investigator.; Serhan CN investigator.; Singh KD investigator.; Slesinger PA investigator.; Snutch TP investigator.; Sobey CG investigator.; Stewart G investigator.; Stoddart LA investigator.; Summers RJ investigator.; Szabo C investigator.; Thwaites D investigator.; Toll L investigator.; Trimmer JS investigator.; Tucker S investigator.; Vaudry H investigator.; Verri T investigator.; Vilargada J‐P investigator.; Waldman SA investigator.; Ward DT investigator.; Waxman SG investigator.; Wei AD investigator.; Willars GB investigator.; Wong SS investigator.; Woodruff TM investigator.; Wulff H investigator.; Ye RD investigator.; Yung Y investigator.; Zajac J‐M investigator.;
• Is Part Of: British journal of pharmacology. Volume 174(2017)Supplement 1
• Page Start: S1
• Page End: S16
• Publication Date: 2017-10-21
• Subjects: Pharmacology -- Periodicals; Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/bph.13882
• Languages: English
• ISSNs: 0007-1188

Abstract

Abstract : The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org ), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found athttp://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full . In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are eight areas of focus: G protein‐coupled receptors, ligand‐gated ion channels, voltage‐gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.