The safety and efficacy of weight loss via intermittent fasting or standard daily energy restriction in adults with type 1 diabetes and overweight or obesity: A pilot study. (December 2018)

• Record Type: Journal Article
• Authors: Overland, Jane; Toth, Krisztina; Gibson, Alice A.; Sainsbury, Amanda; Franklin, Janet; Gauld, Amanda; Wong, Jencia
• Is Part Of: Obesity medicine. Volume 12(2018)
• Page Start: 13
• Page End: 17
• Publication Date: 2018-12
• Subjects: Obesity -- Periodicals; Obesity; Obesity; Periodicals; Periodicals; 616.398005
• DOI: 10.1016/j.obmed.2018.11.001
• Languages: English
• ISSNs: 2451-8476

Abstract

Abstract: Objective: A pilot study to examine the safety and efficacy of weight loss via intermittent fasting or continuous energy restriction in adults with type 1 diabetes and overweight or obesity. Research design and methods: Ten participants with type 1diabetes and overweight or obesity (8 women, 2 men) were randomised to either severe energy restriction (2510 kilojoules per day) on two 24-hour periods per week with 5 days per week of eating to appetite, or continuous moderate energy restriction (30% relative to weight maintenance energy needs) for 12 weeks. Participants were followed to 12 months. Results: There were no adverse events during the study, and rates of hypoglycaemia were unchanged. Body weight was reduced from baseline (P < 0.05) by both intermittent fasting (−7.0%, range −5.2% to −8.0%) and continuous energy restriction (−3.9%, range −1.0% to −11.1%). Trunk fat was also reduced by these two interventions (P < 0.05) (−12.2%, range −1.0% to −15.3% and −10.1%, range 2.3% to −10.7%, respectively). Blood pressure and circulating concentrations of HbA1c and lipids remained unchanged from baseline. There were no between group differences in these outcomes. Conclusion: These findings suggest that both intermittent fasting or continuous energy restriction are safe and effective weight loss approaches for people with type 1 diabetes and overweight or obesity.