Mesolimbic connectivity signatures of impulsivity and BMI in early adolescence. (1st January 2019)

• Record Type: Journal Article
• Authors: Sharkey, Rachel J.; Bourque, Josiane; Larcher, Kevin; Mišić, Bratislav; Zhang, Yu; Altınkaya, Ayça; Sadikot, Abbas; Conrod, Patricia; Evans, Alan C.; Garavan, Hugh; Leyton, Marco; Séguin, Jean R.; Pihl, Robert; Dagher, Alain
• Is Part Of: Appetite. Volume 132(2019)
• Page Start: 25
• Page End: 36
• Publication Date: 2019-01-01
• Subjects: Adolescence -- Impulsivity -- Sensation-Seeking -- BMI -- Resting state fMRI; IMP Impulsivity -- SS Sensation-Seeking -- SN Substantia Nigra -- VTA Ventral tegmental area -- VS Ventral Striatum -- STN Sub-Thalamic Nucleus -- SURPS Substance Use Risk Profile Scale -- AS Anxiety Sensitivity -- BMIZ BMI Z-Score for Age -- FAS Family Affluence Scale -- rsfMRI resting state functional MRI -- FSL FMRIB's Software Library -- ICA Independent Component Analysis -- PLS Partial Least Squares; Food habits -- Periodicals; Appetite -- Periodicals; Appetite disorders -- Periodicals; Electronic journals; 306.4613
• DOI: 10.1016/j.appet.2018.09.019
• Languages: English
• ISSNs: 0195-6663

Abstract

Abstract: Across age groups, differences in connectivity of the mesolimbic and the prefrontal cortex co-vary with trait impulsivity and sensation-seeking. Impulsivity and sensation-seeking are also known to increase during early adolescence as maturation of subcortical structures outpaces that of the prefrontal cortex. While an imbalance between the striatum and prefrontal cortex is considered a normal developmental process, higher levels of adolescent impulsivity and sensation-seeking are associated with an increased risk for diverse problems, including obesity. To determine how the relationship between sensation-seeking, impulsivity and body mass index (BMI) is related to shared neural correlates we measured their relationships with the connectivity of nuclei in the striatum and dopaminergic midbrain in young adolescents. Data were collected from 116 children between the ages of 12 and 14, and included resting state functional magnetic resonance imaging, personality measures from the Substance Use Risk Profile Scale, and BMI Z-score for age. The shared variance for the connectivity of regions of interest in the substantia nigra, ventral tegmental area, ventral striatum and sub-thalamic nucleus, personality measures and BMI Z-score for age, were analyzed using partial least squares correlation. This analysis identified a single significant striato-limbic network that was connected with the substantia nigra, ventral tegmental area and sub-thalamic nuclei (p = 0.002). Connectivity within this network which included the hippocampi, amygdalae, parahippocampal gyri and the regions of interest, correlated positively with impulsivity and BMI Z-score for age and negatively with sensation-seeking. Together, these findings emphasize that, in addition to the well-established role that frontostriatal circuits play in the development of adolescent personality traits, connectivity of limbic regions with the striatum and midbrain also impact impulsivity, sensation-seeking and BMI Z-score in adolescents.