An Efficient Synthesis of (+)‐Subersic Acid. Issue 6 (10th June 2015)

• Record Type: Journal Article
• Authors: Wang, Jing; Wang, Peiqiang; Li, Jue; Wu, Peiying; Ren, Jiangmeng; Zeng, Bubing
• Is Part Of: Chinese journal of chemistry. Volume 33:Issue 6(2015:Jun.)
• Page Start: 679
• Page End: 682
• Publication Date: 2015-06-10
• Subjects: (+)‐subersic acid -- (−)‐Sclareol -- cross coupling -- Heck reaction; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201500219
• Languages: English
• ISSNs: 1001-604X

Abstract

Abstract: This paper describes a concise and practical route to (+)‐subersic acid from naturally occurring (−)‐Sclareol in 7 steps. The key step of this route relied on the cross coupling of the diterpene with the arene fragment using the arylation of allylic acetate followed by β ‐acetoxy elimination type Heck reaction. Abstract : A seven‐step synthetic route was developed to synthesize (+)‐subersic acid from (−)‐Sclareol. The cross coupling of the diterpene with the arene fragment using the arylation of allylic acetate followed by β ‐acetoxy elimination type Heck reaction was acted as the key reaction.