Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis. (7th March 2017)

• Record Type: Journal Article
• Authors: Kurek, Maksymilian; Carnoy, Matthias; Larsen, Peter E.; Nielsen, Line H.; Hansen, Ole; Rades, Thomas; Schmid, Silvan; Boisen, Anja
• Is Part Of: Angewandte Chemie. Volume 129:Number 14(2017)
• Page Start: 3959
• Page End: 3963
• Publication Date: 2017-03-07
• Subjects: IR-Spektroskopie -- Kristallisation -- Nanomechanik -- Nanopartikel; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201700052
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Standard infrared spectroscopy techniques are well‐developed and widely used. However, they typically require milligrams of sample and can involve time‐consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM‐IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM‐IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.