An Electrophilic Reagent for the Direct Introduction of the SCF2PO(OEt)2 Group to Molecules. (26th September 2016)

• Record Type: Journal Article
• Authors: Xiong, Heng‐Ying; Bayle, Alexandre; Pannecoucke, Xavier; Besset, Tatiana
• Is Part Of: Angewandte Chemie. Volume 128:Number 43(2016)
• Page Start: 13688
• Page End: 13692
• Publication Date: 2016-09-26
• Subjects: Difluormethylthiolierung -- Elektrophile Reagentien -- Fluor -- Schwefel -- Synthesemethoden; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201607231
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: An unprecedented electrophilic difluoromethylthiolating reagent (MesNHSCF2 PO(OEt)2 ) was designed. Under mild and metal‐free conditions, this new reagent reacted with various nucleophiles, thus offering an efficient and operationally simple tool for the construction of C−SCF2 PO(OR)2, N−SCF2 PO(OR)2, and S−SCF2 PO(OR)2 bonds. Finally, thanks to this new methodology, the synthesis of the non‐stereoidal anti‐inflammatory diflumidone was achieved.