Complications preceding early deaths in Black and White children with acute myeloid leukemia. Issue 12 (20th July 2017)

• Record Type: Journal Article
• Authors: Winestone, Lena E.; Getz, Kelly D.; Miller, Tamara P.; Li, Yimei; Huang, Yuan‐Shung; Seif, Alix E.; Fisher, Brian T.; Aplenc, Richard
• Is Part Of: Pediatric blood & cancer. Volume 64:Issue 12(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-07-20
• Subjects: AML -- disparities -- intensive care -- mortality -- outcomes research -- race; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26712
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Black patients have a twofold increased risk of induction mortality compared to White patients with acute myeloid leukemia (AML). We reviewed diagnosis and billing data from Pediatric Health Information System for 28 AML Induction I deaths to investigate conditions preceding death in White and Black patients. Half of deaths occurred within 10 days of initial diagnostic admission. Respiratory, cardiac, renal, and infectious complications were common prior to both White and Black deaths. Deaths in White patients were more commonly preceded by intracranial hemorrhage compared to deaths in Black patients. Future studies should assess management approaches of complications by race to identify modifiable processes that reduce mortality.