Presenting features and imaging in childhood acute myeloid leukemia with central nervous system involvement. Issue 12 (24th February 2017)

• Record Type: Journal Article
• Authors: Ranta, Susanna; Palomäki, Maarit; Levinsen, Mette; Taskinen, Mervi; Abrahamsson, Jonas; Hasle, Henrik; Jahnukainen, Kirsi; Heyman, Mats; Harila‐Saari, Arja
• Is Part Of: Pediatric blood & cancer. Volume 64:Issue 12(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02-24
• Subjects: acute myeloid leukemia -- CNS -- MRI -- pediatric; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26459
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Central nervous system (CNS) involvement in childhood acute myeloid leukemia (AML) can manifest as leukemic cells in the cerebrospinal fluid, a solid CNS tumor, or as neurological symptoms. We evaluated the presenting symptoms and neuroimaging findings in 33 of 34 children with AML and CNS involvement at diagnosis in the period 2000–2012 in Sweden, Finland, and Denmark. Imaging was performed in 22 patients, of whom 16 had CNS‐related symptoms. Seven patients, including all but two with facial palsy, had mastoid cell opacification, considered an incidental finding. The frequent involvement of the mastoid bone with facial palsy warrants evaluation in larger series.