Restricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels. Issue 1 (1st January 2017)

• Record Type: Journal Article
• Authors: Song, Eun Ji; Jeon, Seong Gak; Kim, Kyoung Ah; Kim, Jin-il; Moon, Minho
• Is Part Of: Neurogenesis. Volume 4:Issue 1(2017)
• Publication Date: 2017-01-01
• Subjects: adult neurogenesis -- CD4+ T cells -- learning and memory -- OT-II mice -- Th2 cytokines; Neurogenesis -- Periodicals; Periodicals; 612.64018
• DOI: 10.1080/23262133.2016.1256856
• Languages: English
• ISSNs: 2326-2133

Abstract

ABSTRACT: Despite the effects of CD4+ T cell dysfunction on cognitive and behavioral impairment are well established, the effects of Th2 cytokines on the adult hippocampal neurogenesis and cognitive function in restricted CD4+ T cell receptor (TCR) repertoire model have not been fully elucidate. We found that mice with restricted CD4+ repertoire TCR showed decreased adult hippocampal neurogenesis using OT-II mice. Moreover, we demonstrated that OT-II mice showed increased Th2 cytokine levels in peripheral organs and IL-4 levels in brain. Taken together, altered Th2 cytokine levels may impact learning and memory via impaired adult neurogenesis in restricted CD4+ repertoire TCR mice.