PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN. (2nd November 2017)
- Record Type:
- Journal Article
- Title:
- PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN. (2nd November 2017)
- Main Title:
- PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN
- Authors:
- Gupta, Amit
Anjomani-Virmouni, Sara
Koundouros, Nikos
Poulogiannis, George - Abstract:
- ABSTRACT: Cancer and Parkinson disease (PD) derive from distinct alterations in cellular processes, yet there are pathogenic mutations that are unequivocally linked to both diseases. Here we expand on our recent findings that loss of parkin RBR E3 ubiquitin protein ligase ( PRKN, best known as PARK2 )—which is genetically linked to PD—promotes cancer progression via redox-mediated inactivation of phosphatase and tensin homolog (PTEN) by S-nitrosylation.
- Is Part Of:
- Molecular & cellular oncology. Volume 4:Number 6(2017)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 4:Number 6(2017)
- Issue Display:
- Volume 4, Issue 6 (2017)
- Year:
- 2017
- Volume:
- 4
- Issue:
- 6
- Issue Sort Value:
- 2017-0004-0006-0000
- Page Start:
- Page End:
- Publication Date:
- 2017-11-02
- Subjects:
- Cancer -- nitrosative stress -- PARK2 -- PTEN -- S-nitrosylation
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2017.1329692 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 8578.xml