68Ga-PSMA Uptake in Neurofibromas Demonstrated on PET/CT in a Patient With Neurofibromatosis Type 1. (October 2017)

• Record Type: Journal Article
• Authors: Gulhane, Brook; Ramsay, Stuart; Fong, William
• Is Part Of: Clinical nuclear medicine. Volume 42:Number 10(2017)
• Publication Date: 2017-10
• Subjects: malignant peripheral nerve sheath tumor -- neurofibroma -- neurofibromatosis -- PET -- PSMA -- von Recklinghausen disease; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001777
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: We present a case of 68 Ga-PSMA PET/CT imaging of PSMA expression in neurofibromas in a patient with neurofibromatosis type 1 (or von Recklinghausen disease). PSMA uptake has previously been demonstrated in schwannomas both with PET and histological staining. The presented images confirm that PSMA expression in cutaneous neurofibromas can be well imaged with PET, with uptake mostly at relatively low levels. Interestingly, some lesions demonstrated significantly higher PSMA expression, although the clinical significance of these differences remains to be determined. The images raise the possibility of a potential role for 68 Ga-PSMA PET/CT in neurofibromatosis type 1 monitoring.