Evaluation of polyvinyl alcohol composite membranes containing collagen and bone particles. (August 2015)

• Record Type: Journal Article
• Authors: Hameed, Nishar; Glattauer, Veronica; Ramshaw, John A.M.
• Is Part Of: Journal of the mechanical behavior of biomedical materials. Volume 48(2015)
• Page Start: 38
• Page End: 45
• Publication Date: 2015-08
• Subjects: Polyvinyl alcohol -- Bone -- Demineralised bone -- Thermal properties -- Mechanical properties -- Cell culture; Biomedical materials -- Periodicals; Biomedical materials -- Mechanical properties -- Periodicals; Biomedical materials; Biomedical materials -- Mechanical properties; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.jmbbm.2015.04.005
• Languages: English
• ISSNs: 1751-6161

Abstract

Abstract: Composite biomaterials provide alternative materials that improve on the properties of the individual components and can be used to replace or restore damaged or diseased tissues. Typically, a composite biomaterial consists of a matrix, often a polymer, with one or more fillers that can be made up of particles, sheets or fibres. The polymer matrix can be chosen from a wide range of compositions and can be fabricated easily and rapidly into complex shapes and structures. In the present study we have examined three size fractions of collagen-containing particles embedded at up to 60% w/w in a poly(vinyl alcohol) (PVA) matrix. The particles used were bone particles, which are a mineral–collagen composite and demineralised bone, which gives naturally cross-linked collagen particles. SEM showed well dispersed particles in the PVA matrix for all concentrations and sizes of particles, with FTIR suggesting collagen to PVA hydrogen bonding. T g of membranes shifted to a slightly lower temperature with increasing collagen content, along with a minor amount of melting point depression. The modulus and tensile strength of membranes were improved with the addition of both particles up to 10 wt%, and were clearly strengthened by the addition, although this effect decreased with higher collagen loadings. Elongation at break decreased with collagen content. Cell adhesion to the membranes was observed associated with the collagen particles, indicating a lack of cytotoxicity. Graphical abstract: Highlights: Novel composite membranes of a poly(vinyl alcohol) matrix and collagen particles have been made. The collagen particles were bone and demineralised bone, as three separate size fractions. FTIR suggests collagen to poly(vinyl alcohol) hydrogen bonding. The modulus and tensile stress of membranes were strengthened by addition of particles up to 10 wt%. Preliminary cell adhesion tests on membranes indicated a lack of cytotoxicity.