A Review of the Molecular Basis for Reduced Endometrial Receptivity in Uterine Fibroids and Polyps. Issue 4 (October 2017)

• Record Type: Journal Article
• Authors: Narula, Shagun; Harris, Amani; Tsaltas, Jim
• Is Part Of: Journal of endometriosis and pelvic pain disorders. Volume 9:Issue 4(2017)
• Page Start: 239
• Page End: 244
• Publication Date: 2017-10
• Subjects: Endometrium -- Fertility -- Fibroids -- HOX -- Polyps; Endometriosis -- Periodicals; Pelvic pain -- Periodicals; 618.1
• DOI: 10.5301/jeppd.5000304
• Languages: English
• ISSNs: 2284-0265

Abstract

The presence of fibroids and endometrial polyps is associated with reduced endometrial receptivity and subsequent fertility outcomes. The following review explores the molecular mechanisms behind reduced endometrial receptivity, with a focus upon homebox genes, basic transcription element binding proteins, transforming growth factor β-3, and bone morphogenetic protein 2. A better understanding of these processes is essential for future targeted therapy.