Synthesis of oxidized β-cyclodextrin with high aqueous solubility and broad-spectrum antimicrobial activity. (1st December 2017)

• Record Type: Journal Article
• Authors: Ye, Youxin; Ren, He; Zhu, Shu; Tan, Huan; Li, Xinying; Li, Defu; Mu, Changdao
• Is Part Of: Carbohydrate polymers. Volume 177(2017)
• Page Start: 97
• Page End: 104
• Publication Date: 2017-12-01
• Subjects: Oxidized β-cyclodextrin -- Hydrogen peroxide -- Antimicrobial activity -- Antifungal activity -- Fruit preservation; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2017.08.123
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Oxidized β-cyclodextrins with different oxidation levels were synthesized. Aqueous solubility of oxidized β-cyclodextrin was highly improved. Oxidized β-cyclodextrin presented a broad-spectrum antimicrobial activity. Growth of A. niger spores was efficiently inhibited by oxidized β-cyclodextrin. Oxidized β-cyclodextrin could effectively extend the storage time of apple. Abstract: Oxidized β-cyclodextrins with different oxidation levels were prepared using hydrogen peroxide as the oxidant and copper sulfate as the catalyst. The physicochemical, antimicrobial and antifungal properties of oxidized β-cyclodextrin were systematically studied. The results showed that the oxidation level of oxidized β-cyclodextrin was successfully controlled by adjusting the dosage of hydrogen peroxide. The aqueous solubility of oxidized β-cyclodextrin was highly improved as expected. However, oxidation changed the morphology and partly reduced the crystallinity of oxidized β-cyclodextrin due to the introduced carbonyl and carboxyl groups. It is interesting that oxidized β-cyclodextrin presented a broad-spectrum antimicrobial activity, which was efficiently improved with the increasing oxidation level. Growth of A. niger spores was efficiently inhibited in the presence of oxidized β-cyclodextrin. Moreover, oxidized β-cyclodextrin could effectively extend the storage time of apple. In summary, oxidized β-cyclodextrin shows potential as antimicrobial and antifungal agents in food industry.