Dosing characteristics of oral treprostinil in real-world clinical practice. (July 2018)

• Record Type: Journal Article
• Authors: Balasubramanian, Vijay P.; Messick, Chad R.; Broderick, Meredith; Nelsen, Andrew C.
• Is Part Of: Pulmonary circulation. Volume 8:Number 2(2018)
• Publication Date: 2018-07
• Subjects: treprostinil -- oral treprostinil -- dosing -- real-world use; Pulmonary circulation -- Periodicals; Pulmonary circulation; Electronic journals -- Sciences; Periodicals; 616.24005
• DOI: 10.1177/2045894018770654
• Languages: English
• ISSNs: 2045-8932

Abstract

Pharmacokinetic studies with oral treprostinil demonstrate that three times daily (TID) dosing reduces peak-to-trough plasma trepostinil fluctuations compared with twice daily (BID) dosing. TID dosing may allow for faster titration, higher total daily doses, and potentially improve the tolerability of oral trepostinil. This analysis, which looks at the real-world dosing of oral treprostinil, supports the utility of TID dosing.