S-Nitrosothiols—NO donors regulating cardiovascular cell proliferation: Insight into intracellular pathway alterations. (September 2016)

• Record Type: Journal Article
• Authors: Rychter, Marek; Gaucher, Caroline; Boudier, Ariane; Leroy, Pierre; Lulek, Janina
• Is Part Of: International journal of biochemistry & cell biology. Volume 78(2016:Sep.)
• Page Start: 156
• Page End: 161
• Publication Date: 2016-09
• Subjects: EDRF endothelium-derived relaxing factor -- sGC soluble guanylate cyclase -- cGMP cyclic guanosine monophosphate -- RSNO S-nitrosothiol -- GSNO S-nitrosoglutathione -- PTM post-translational modifications -- NOS nitric oxide synthase -- GTP guanosine triphospate -- cGMP cyclic guanosine monophosphate -- VSMC vascular smooth muscle cells -- ACh acetylcholine -- VEGF vascular endothelial growth factor -- BDK bradykinin -- eNOS endothelial nitric oxide synthase -- PRT protein -- Trx thioredoxin -- VASP vasodilator-stimulated phosphoprotein -- EGF epidermal growth factor -- 26P 26S proteasome -- TNFα tumor necrosis factor alpha -- CDKN1A cyclin-dependent kinase inhibitor 1A -- Rap1GAP Rap1 GTPase-activating protein 1 -- mPTP mitochondrial permeability transition pore -- g-GT g-glutamyl transpeptidase -- CGNO S-nitrosocysteinylglycine -- Cys-NO S-nitrosocysteine -- PDI protein disulfide isomerase; Nitric oxide -- S-Nitrosothiols -- S-Nitrosation -- S-Glutathionylation -- Cell proliferation; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2016.07.003
• Languages: English
• ISSNs: 1357-2725

Abstract

Highlights: cGMP dependent and independent mechanism of NO based signaling pathways modulates vascular cell proliferation cGMP independent mechanism occurs through cysteine S -nitrosation and S -glutathionylation, tyrosine nitration of proteins. Further insight into NO based signaling pathway can be found athttp://www.sfrbm.org/sections/education/frs-presentations . Abstract: Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) activates signaling pathways responsible for smooth muscle cell relaxation, leading to vasodilation and thus plays an important role in controlling vascular homeostasis, thrombosis and inflammation. Recent studies indicate that S- nitrosothiols produced in vivo as well as synthetic ones might be important reservoirs of NO. Based on a broad range of NO functions within the living organisms, this review highlights the impact of S -nitrosothiols on cardiovascular cell cycle. The cell membrane transport and the decomposition patterns responsible of S -nitrosothiols actions are presented. The effects of NO delivery through S -nitrosothiols have a significant potential in cardiovascular diseases with various underlying causes. The challenges related to their application in the pharmacotherapy of patients with various cardiovascular diseases are also discussed.