Sulfur‐containing gaseous signal molecules, ion channels and cardiovascular diseases. (30th May 2017)

• Record Type: Journal Article
• Authors: Yu, Wen; Jin, Hongfang; Tang, Chaoshu; Du, Junbao; Zhang, Zhiren
• Is Part Of: British journal of pharmacology. Volume 175:Number 8(2018)
• Page Start: 1114
• Page End: 1125
• Publication Date: 2017-05-30
• Subjects: Pharmacology -- Periodicals; Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/bph.13829
• Languages: English
• ISSNs: 0007-1188

Abstract

Abstract : Sulfur‐containing gaseous signal molecules including hydrogen sulphide and sulfur dioxide were previously recognized as toxic gases. However, extensive studies have revealed that they can be generated in the cardiovascular system via a sulfur‐containing amino acid metabolic pathway, and have an important role in cardiovascular physiology and pathophysiology. Ion channels are pore‐formingmembrane protein s present in the membrane of all biological cells; their functions include the establishment of aresting membrane potential and the control ofaction potentials and other electrical signals by conductingions across the cell membrane. Evidence has now accumulated suggesting that the sulfur‐containing gaseous signal molecules are important regulators of ion channels and transporters. The aims of this review are (1) to discuss the recent experimental evidences in the cardiovascular system regarding the regulatory effects of sulfur‐containing gaseous signal molecules on a variety of ion channels, including ATP‐sensitive potassium, calcium‐activated potassium, voltage‐gated potassium, L‐ and T‐type calcium, transient receptor potential and chloride and sodium channels, and (2) to understand how the gaseous signal molecules affect ion channels and cardiovascular diseases. Linked Articles: This article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visithttp://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc