Long‐term outcomes of transplant recipients referred for angiography for suspected transplant renal artery stenosis. (14th July 2015)

• Record Type: Journal Article
• Authors: Ali, Anum; Mishler, Dennis; Taber, Tim; Agarwal, David; Yaqub, Muhammad; Mujtaba, Muhammad; Goggins, William; Sharfuddin, Asif
• Is Part Of: Clinical transplantation. Volume 29:Number 9(2015)
• Page Start: 747
• Page End: 755
• Publication Date: 2015-07-14
• Subjects: graft function -- graft survival -- hypertension -- kidney transplant -- transplant renal artery stenosis; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.12574
• Languages: English
• ISSNs: 0902-0063

Abstract

Abstract: Our aim was to study the long‐term outcomes of all transplant recipients who underwent angiography for suspected TRAS at our institution. The patients were divided into TRAS+ve and TRAS−ve groups based upon angiographically confirmed results. TRAS was confirmed in 58.1% of 74 patients with median time of 8.9 months. Primary angioplasty alone was performed in 56% of patients with TRAS, while the remaining had PTA with stent (PTAS). There was reduction in systolic and diastolic BP (165 ± 19–136 ± 15 mmHg and 82 ± 14 mmHg to 68 ± 12 mmHg; p < 0.05) and number of antihypertensive drugs (3.5 ± 0.9–2.7 ± 1.0; p < 0.05). Overall, graft survival and patient survival from time of transplant were similar in both groups. Graft function was similar for the patients with treated TRAS+ve as compared to TRAS−ve over time. Graft survival and patient survival when compared to an age‐ and year of transplant‐matched cohort control group were also similar. In conclusion, angiography for suspected TRAS is more likely to yield a confirmatory result early in the transplant course as compared to late. Treatment of TRAS in these patients had sustained long‐term graft function. Alternative etiologies of HTN and graft dysfunction should be sought for recipients further out from transplant.