Wobble uridine tRNA modification: a new vulnerability of refractory melanoma. (2nd November 2018)

• Record Type: Journal Article
• Authors: Rapino, Francesca; Close, Pierre
• Is Part Of: Molecular & cellular oncology. Volume 5:Number 6(2018)
• Publication Date: 2018-11-02
• Subjects: wobble tRNA modification -- mRNA translation -- HIF1α -- melanoma -- targeted therapy; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2018.1513725
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: The enzymes catalysing the modification of the wobble uridine (U34 ) of tRNAs (U34 -enzymes) play an important role in tumor development. We have recently demonstrated that the U34 -enzymes are crucial in the survival of glycolytic melanoma cultures through a codon-specific regulation of HIF1α mRNA translation. Moreover, depletion of U34 -enzymes resensitizes resistant melanoma to targeted therapy. These results indicate that targeting U34 -enzymes represents a new therapeutic opportunity for melanoma patients.