Optimum designs for mixtures with relational constraints on the components. (1st January 2013)

• Record Type: Journal Article
• Authors: Pal, Manisha; Mandal, Nripes Kumar
• Is Part Of: International journal of experimental design and process optimisation. Volume 3:Number 3(2013)
• Page Start: 276
• Page End: 293
• Publication Date: 2013-01-01
• Subjects: mixture experiment -- relational constraint -- major and minor components -- D-optimality -- trace-optimality; Experimental design -- Periodicals; Process control -- Statistical methods -- Periodicals; 620.0072
• Languages: English
• ISSNs: 2040-2252

Abstract

In many experimentations with mixtures, the classical mixture models are found to be inappropriate to describe the response. In pharmaceutical research, for example, the components of the mixture are often classified into groups and the proportions of different groups in the mixture are fixed. This results in relational constraints on the mixing components. In the paper, we study a mixture model appropriate in such a situation. We attempt to find optimum designs for estimation of parameters in the model, and also for estimation of the optimum proportions of components in a group. The support points of the optimum designs are found to belong to the union of barycentres of the domains of the groups involved.