Detection of early osteoarthritis in canine knee joints 3 weeks post ACL transection by microscopic MRI and biomechanical measurement. (5th June 2018)

• Record Type: Journal Article
• Authors: Mittelstaedt, Daniel; Kahn, David; Xia, Yang
• Is Part Of: Journal of orthopaedic surgery. Volume 26:Number 2(2018)
• Publication Date: 2018-06-05
• Subjects: anterior cruciate ligament transection -- biomechanical modulus -- depth dependence -- microscopic MRI -- osteoarthritis -- topographical variation; Orthopedic surgery -- Periodicals; Orthopedics; Orthopedic surgery; Periodicals; 617.3
• DOI: 10.1177/2309499018778357
• Languages: English
• ISSNs: 1022-5536

Abstract

Purpose: To detect early osteoarthritis (OA) in a canine Pond–Nuki model 3 weeks after anterior cruciate ligament (ACL) transection surgery, both topographically over the medial tibial surface and depth-dependently over the cartilage thickness. Methods: Four topographical locations on each OA and contralateral medial tibia were imaged individually by magnetic resonance imaging (MRI) at 17.6 µm transverse resolution. The quantitative MRI T 2 relaxation data were correlated with the biomechanical stress-relaxation measurements from adjacent locations. Results: OA cartilage was thinner than the contralateral tissue and had a lower modulus compared to the contralateral cartilage for the exterior, interior, and central medial tibia locations. Depth-dependent and topographical variations were detected in OA cartilage by a number of parameters (compressive modulus, glycosaminoglycan concentration, bulk and zonal thicknesses, T 2 at 0° and 55° specimen orientations in the magnet). T 2 demonstrated significant differences at varying depths between OA and contralateral cartilage. Conclusion: ACL transection caused a number of changes in the tibial cartilage at 3 weeks after the surgery. The characteristics of these changes, which are topographic and depth-dependent, likely reflect the complex degradation in this canine model of OA at the early developmental stage.