DNA methylation changes in CD4+ T cells isolated from multiple sclerosis patients on dimethyl fumarate. Issue 3 (July 2018)

• Record Type: Journal Article
• Authors: Maltby, Vicki E; Lea, Rodney A; Ribbons, Karen A; Sanders, Katherine A; Kennedy, Daniel; Min, Myintzu; Scott, Rodney J; Lechner-Scott, Jeannette
• Is Part Of: Multiple sclerosis journal, experimental, translational and clinical. Volume 4:Issue 3(2018)
• Publication Date: 2018-07
• Subjects: Multiple sclerosis -- dimethyl fumarate -- immunology -- DNA methylation -- relapsing–remitting -- CD4+ T cells -- tumour necrosis factor; Multiple sclerosis -- Periodicals; 616.834
• DOI: 10.1177/2055217318787826
• Languages: English
• ISSNs: 2055-2173

Abstract

Background: Dimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood. Objective: To investigate the effects of dimethyl fumarate on DNA methylation in the CD4 + T cells of multiple sclerosis patients. Methods: We performed Illumina EPIC arrays to investigate the DNA methylation profiles of CD4 + T cells derived from multiple sclerosis patients before and after dimethyl fumarate treatment. Results: Treatment with dimethyl fumarate resulted in 97% of differentially methylated positions showing hypermethylation. Four genes, SNORD1A, SHTN1, MZB1 and TNF had a differentially methylated region located within the transcriptional start site. Conclusion: This study investigates the effect of dimethyl fumarate on DNA methylation in multiple sclerosis patients.