Adolescents' and Parents' Attitudes Toward Adolescent Clinical Trial Participation: Changes Over One Year. (October 2018)

• Record Type: Journal Article
• Authors: Tsevat, Rebecca K.; Radecki Breitkopf, Carmen; Landers, Sara E.; de Roche, Ariel M.; Mauro, Christine; Ipp, Lisa S.; Catallozzi, Marina; Rosenthal, Susan L.
• Is Part Of: Journal of empirical research on human research ethics. Volume 13:Number 4(2018)
• Page Start: 383
• Page End: 390
• Publication Date: 2018-10
• Subjects: adolescent health -- clinical trials -- decision-making -- parental influence -- reproductive health; Medical ethics -- Research -- Periodicals; Research -- Moral and ethical aspects -- Periodicals; 174.205
• DOI: 10.1177/1556264618790889
• Languages: English
• ISSNs: 1556-2646

Abstract

Little is known about how adolescents' and parents' thoughts about participation in clinical trials change over time. In this study, adolescent (14-17 years)–parent dyads were asked about willingness to participate in a hypothetical reproductive health study. A year later, they were asked how their thoughts about the study had changed. Qualitative responses were coded and analyzed using framework analysis. Thirty-two percent of adolescents and 18% of parents reported changes in thoughts; reasons included general changes in perception, clearer understanding, new knowledge or experiences, increased maturity/age of adolescents, and changes in participants independent of the study. Adolescents and parents may benefit from learning about studies multiple times, and investigators should account for development and new experiences to optimize adolescent research enrollment.