Evaluation of age‐dependent changes of myocardial velocity using pulsed wave and colour tissue Doppler imaging in adult warmblood horses. Issue 6 (19th July 2018)

• Record Type: Journal Article
• Authors: Gehlen, Heidrun; Bildheim, Lisa‐Marie
• Is Part Of: Journal of animal physiology and animal nutrition. Volume 102:Issue 6(2018)
• Page Start: 1731
• Page End: 1742
• Publication Date: 2018-07-19
• Subjects: ageing -- horse -- myocardium -- tissue doppler; Animal nutrition -- Periodicals; Feeds -- Periodicals; 636.085
• DOI: 10.1111/jpn.12962
• Languages: English
• ISSNs: 0931-2439

Abstract

Abstract: Our aim was to evaluate the influence of the ageing process on the myocardium using pulsed wave tissue Doppler (PW‐TDI) and colour tissue Doppler imaging (cTDI) to measure myocardial velocities at three different myocardial regions (right ventricular free wall: RVFW, interventricular septum: IVS, left ventricular free wall: LVFW). A total of 60 healthy warmblood horses, aged from 3 to 30 years, were examined. The horses were divided into five age groups (group 1: 3–8 years, n = 14; group 2: 9–13 years, n = 9; group 3: 14–18 years, n = 10; group 4: 19–23 years, n = 14; group 5: 24–30 years, n = 10). The results showed that age has a significant influence on the radial myocardial velocity of horses in different myocardial regions. This influence was detectable by both echocardiographic techniques, although PW‐TDI measurements showed a higher reproducibility due to lower intraindividual variation coefficients. Systolic contraction velocity ( p ≤ 0.01) and early diastolic relaxation velocity ( p ≤ 0.001) in the LVFW decreased significantly with ageing, while late diastolic contraction velocity increased (0.001 < p ≤ 0.01). Early and late diastolic contraction velocities at the IVS increased significantly with ageing ( p ≤ 0.001). Systolic and late‐diastolic contraction velocities at the RVFW increased significantly with ageing ( p ≤ 0.001). The results indicated a decrease in left ventricular contraction ability and reduced myocardial relaxation and altered diastolic function in the right ventricle with increasing age. These functional changes may be signs of age‐related structural myocardial changes or cardiac remodelling, such as increased myocardial stiffness. Thus, an assessment of the radial myocardial velocities of a horse's heart with TDI should always consider physiological age‐related changes in contractility. Comparing the two examination techniques (PW‐TDI and cTDI) we used in our study, we found that both methods showed comparable age‐related alterations. Nevertheless, differences in absolute values were found with a tendency of higher values using PW‐TDI in comparison to cTDI.